Event Date: Mar 25, 2021
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Cognitive impairment is the hallmark of Alzheimer’s disease (AD) and related dementias. However, motor decline, specifically slowing speed in the way we walk, has been recently described as a prodromal state that can help to detect at-risk individuals. Similarly, hearing changes, sleep and behavior disturbances have been associated with higher risk of developing dementia. These clinical findings, together with the recognition that AD pathology precedes the diagnosis by many years, raises the possibility that non-cognitive changes may be early and non-invasive markers for AD or, even more provocatively, that treating non-cognitive aspects may help to prevent or treat AD and related dementias.
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