Higlights of Canadian research and policy news.

This news brought to you by the Murray Alzheimer Research and Education Program and brainXchange. 

Benzodiazepines and Alzheimer's Disease


Monday, August 20, 2018

Benzodiazepines are commonly used for sleep problems but are widely known for their negative side effects. Especially with older adults, the adverse effects can cause drowsiness and falls, which can lead to injury. A study out of the University of Eastern Finland found that benzodiazepines and related drugs increase Alzheimer’s disease risk as well.

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Benzodiazepines and Alzheimer's Disease

Monday, August 20, 2018

Benzodiazepines are commonly used for sleep problems but are widely known for their negative side effects. Especially with older adults, the adverse effects can cause drowsiness and falls, which can lead to injury. A study out of the University of Eastern Finland found that benzodiazepines and related drugs increase Alzheimer’s disease risk as well.

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Why Do Some People With Plaques and Tangles Not Develop Dementia?

Monday, August 20, 2018

A primary pathology of Alzheimer’s disease is the accumulation of neurofibrillary tangles and amyloid beta plaques. These proteins clump and stick together in the brain and disrupt normal signalling pathways. However, some people who have plaques and tangles in their brains do not show symptoms of Alzheimer’s disease. Research from the University of Texas Medical Branch at Galveston may have the answer. Through mass spectrometry and electrophoresis, researches analyzed the protein composition of synapses from donated brain tissue from individuals who were part of past brain aging studies.

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New Research Suggests a Different Cause of Alzheimer's Disease

Monday, August 20, 2018

A group of researchers led by a team from the University of Adelaide, now suggest that early onset Alzheimer's disease that is inherited through a familial line may be the result of a genetic mutation in how cells handle iron. Cells need iron in order for the mitochondria to function properly, which is vital for the survival of the cell. If a genetic mutation affects a gene within the process of handling and recycling iron, Alzheimer's disease can develop.

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MAREP to join Research Institute for Aging

Wednesday, August 15, 2018

This fall, the Murray Alzheimer Research and Education Program (MAREP) will move its home base from the Faculty of Applied Health Sciences at the University of Waterloo to the Schlegel-UW Research Institute for Aging (RIA).

Since 1993, MAREP has been improving dementia care practices in Canada and around the world through research and education.

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Treatment for Kidney Failure a Risk for Dementia

Monday, August 13, 2018

Older adults who undergo hemodialysis for kidney failure have been shown to have a decline in cognition at the time of treatment. With this in mind, Dr. Mara McAdams-DeMarcho and her team led research to understand the risk of developing dementia in correlation to hemodialysis treatment.

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It’s all in the eyes

Monday, August 13, 2018

New research from a team of researchers from the University of Washington School of Medicine, the Kaiser Permanente Washington Health Institute and the UW School of Nursing have found a correlation between disease of the eye and development of dementia.

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A New Inhibitor of Amyloid Plaques

Monday, August 13, 2018

Researchers from the Technical University of Munich have come closer to finding a way to combat amyloid plaques, a protein that characterizes in Alzheimer’s disease. They designed a highly potent inhibitor of amyloid plaque formation in a new class of macrocyclic peptides.

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Researcher Focuses on Prevention Rather than Treatment: A Drug Trial

Tuesday, August 7, 2018

With dementia, there are molecular processes and changes in the brain that occur years before symptoms are noticeable. Researchers at the University of Virginia are looking into how dementia develops at the molecular level before neuronal damage and symptoms are present. Specifically, researchers are investigating whether memantine, a medication commonly used in alleviating symptoms of moderate dementia, could slow or prevent progression of dementia if used before symptoms appear.

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Bill Gates Invests in Alzheimer's Disease Detection Development

Tuesday, August 7, 2018

Bill Gates makes headlines again in the world of Alzheimer’s disease after announcing that he will be investing in the Alzheimer’s Drug Discovery Foundation (ADDF). Together with Leonard Lauder, the Dolby family, the Charles and Helen Schwab Foundation and others, they will be donating $30 million to start the Diagnostic Accelerator. This fund will help researchers develop new biomarkers for early detection of Alzheimer’s disease. The ADDF is requesting proposals for research with preliminary data to get into proof of concept studies and validation studies on biomarkers.

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